Industry has taken another important step toward achieving the ability to connect all systems through the Internet of Things. This means information can be captured from any process and turned into value thanks to the application of Big Data and Artificial Intelligence. Advances in cable-free connectivity for wireless and connected factories, improved employee productivity and safety, savings and efficiencies gained from IoT sensor data analytics, predictive maintenance for rapid response and planning, digital realities and twin environments are just some of the trends currently revolutionising the industry. However, becoming a smart factory entails a number of organisational and cultural challenges that not all industries, or people, are ready to face. For us, the main keys that determine this change are: flexible and on-demand manufacturing, improving quality processes, avoiding production line stoppages, factory digitalisation (flexible layouts) and intelligent supply chains.